c-FABP

Fatty Acid Binding Protein (cFABP) is a small cyto-solic protein responsible for the transport and deposition of fatty acids inside the cell. Several different isoforms of FABP are expressed in different tissue types. Cardiac isoform of FABP (cFABP) is expressed mainly in cardiac muscle tissue and in significantly lower concentration in skeletal muscles. Cardiac isoform of FABP consists of 132 amino acid residues with molecular weight 14727 Da and theo-retical pl 6.34. Recently it was demonstrated that cFABP can be used as an early marker of myocardial infarction. cFABP has the same kinetics of liberation into pa-tients blood as myoglobin. Because cFABP concentration is significantly lower in skeletal muscle (com-paring with myoglobin) the concentration of cFABP in the blood of healthy donors is also significantly lower (6 - 10 ng/ml for cFABP and 40 - 60 ng/ml for myoglobin). This fact makes cFABP more sensitive and reliable early marker of myocardial cell death. Recent studies demonstrated that FABP can be use-ful also for the early detection of minor myocardial events such as unstable angina. Switching clinical studies from myoglobin to cFABP can be helpful for the improvement of early AMI diagnosis.

cFABP can be used as an early marker of myocardial infarction. cFABP is more sensitive and reliable early marker of AMI. FABP can be use-ful also for the early detection of minor myocardial events such as unstable angina too. Switching clinical studies from myoglobin to cFABP can be helpful for the improvement of early AMI diagnosis.